解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We examined whether the cholinergic mechanism is involved in the paradoxical GH responses to vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) in acromegaly. 28 patients with active acromegaly underwent i.v. bolus injections of thyrotropin-releasing hormone (TRH, 500 micrograms), GH-releasing ...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/0143-4179(94)90047-7
更新日期:1994-08-01 00:00:00
abstract::A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text sa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90013-2
更新日期:1994-07-01 00:00:00
abstract::Arginine vasopressin mediates its effects through vasopressin receptor activation and second messenger production. Recent cloning of the V1a receptor provided the opportunity to investigate the possible signal transduction pathways associated with this single vasopressin receptor subtype. When stably expressed in CHO ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90017-5
更新日期:1994-07-01 00:00:00
abstract::The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90026-4
更新日期:1994-06-01 00:00:00
abstract::The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90119-8
更新日期:1994-05-01 00:00:00
abstract::A series of biologically active peptides and related compounds (opioid peptides, neurotensin, and bradykinin) were used as substrates or competitive inhibitors to study the structural requirements for peptide interaction with endopeptidase 22.19. The kinetics of hydrolysis of these peptides indicated that, in contrast...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90083-3
更新日期:1994-04-01 00:00:00
abstract::The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90124-4
更新日期:1994-03-01 00:00:00
abstract::Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90043-a
更新日期:1993-11-01 00:00:00
abstract::Several lines of evidence indicate a role for neuropeptide Y (NPY) in the modulation of the corticotroph axis. In two separate studies reported here, the concentrations of NPY and noradrenaline (NA), as well as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), were measured in extracts of individual...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90107-l
更新日期:1993-10-01 00:00:00
abstract::AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90096-s
更新日期:1993-08-01 00:00:00
abstract::Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90065-i
更新日期:1993-07-01 00:00:00
abstract::We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals wit...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90008-x
更新日期:1993-06-01 00:00:00
abstract::Paired-pulse stimulation was used to evaluate the effects of the sulfated octapeptide of cholecystokinin (CCK8-S), the gamma-aminobutyric acidB (GABAB) agonist (-) baclofen, and the GABAA antagonist (-) bicuculline on hippocampal dentate gyrus (DG) granule cell excitability. Evoked action potentials (EAPs) and excitat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90014-2
更新日期:1993-05-01 00:00:00
abstract::In the hot plate test the intracerebroventricular (i.c.v.) injection of oxytocin produced a significant decrease in nociception, starting from the dose of 1 microgram/rat. A comparable effect was obtained with 10-200 times higher intraperitoneal (i.p.) doses. The i.c.v. injection of the oxytocin antagonist d(CH2)5-Tyr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90075-l
更新日期:1993-03-01 00:00:00
abstract::We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90030-e
更新日期:1993-02-01 00:00:00
abstract::Pheochromocytoma (PC-12) cells exposed to nerve growth factor (NGF) acquire a sympathetic neuron-like phenotype. This NGF-response is blocked by methylation inhibitors and can be mimicked by the farnesylated methylated small GTP-binding protein p21ras. The implicated involvement of prenylation, methylation and a small...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90036-a
更新日期:1993-01-01 00:00:00
abstract::In this study the influence of acute exposure of gastric mucosa to the sensory neurotoxin capsaicin on basal gastric acid secretion and on secretion induced by 2-deoxy-D-glucose or histamine in conscious dogs with gastric fistulae has been investigated. Under basal conditions intragastric capsaicin (160 microM, 50 ml ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90128-j
更新日期:1992-12-01 00:00:00
abstract::The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90123-e
更新日期:1992-11-01 00:00:00
abstract::The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90115-d
更新日期:1992-11-01 00:00:00
abstract::Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90002-e
更新日期:1992-09-01 00:00:00
abstract::Somatostatin, substance P, and vasoactive intestinal polypeptide were incubated in an adenylate cyclase assay with a particulate fraction of caudate-putamen tissue of the rat in order to examine the effect of the neuropeptides on G-protein coupled adenylate cyclase in vitro. Somatostatin induced an enhancement of cycl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90156-q
更新日期:1992-07-01 00:00:00
abstract::The effects of several doses of porcine brain natriuretic peptide-32 (pBNP-32) administered into the lateral brain ventricle were tested as regards the consolidation of passive avoidance learning in rats. The peptide was found to increase the passive avoidance latency in a dose-dependent manner. In order to clarify wh...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90064-4
更新日期:1992-06-01 00:00:00
abstract::CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90067-7
更新日期:1992-06-01 00:00:00
abstract::In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90026-s
更新日期:1992-04-01 00:00:00
abstract::Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90025-r
更新日期:1992-04-01 00:00:00
abstract::The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90037-w
更新日期:1992-03-01 00:00:00
abstract::Our previous study showed that intracerebroventricular (ICV) administration of corticotropin-releasing hormone (CRH) produced a significant increase in locomotor activity at a dose of 1 microgram and slow stereotypy with prominent grooming at a dose of 10 micrograms. In addition, the ICV administration of CRH caused a...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90016-c
更新日期:1991-12-01 00:00:00
abstract::Previous behavioural and electrophysiological studies have indicated an antinarcotic action of thyrotropin-releasing hormone (TRH) and its analogues in antagonizing the action of CNS depressant drugs, including baclofen and a variety of anesthetics. While beta-adrenergic receptors are implicated in the level of anaest...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90034-g
更新日期:1991-09-01 00:00:00
abstract::We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90033-f
更新日期:1991-09-01 00:00:00
abstract::The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/0143-4179(91)90079-x
更新日期:1991-07-01 00:00:00
abstract::The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90112-v
更新日期:1991-07-01 00:00:00
abstract::The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章,评审
doi:10.1016/0143-4179(91)90078-w
更新日期:1991-07-01 00:00:00
abstract::Quantitative evaluation of octadecaneuropeptide-like immunoreactivity (ODN-Li) was carried out in hippocampus, cortex and cerebellum of group-reared or three month isolated male Wistar rats, whether muricidal or not. ODN-Li was lower in cortex and cerebellum of isolated animals, (mainly in muricidal) than of group-rea...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90116-z
更新日期:1991-07-01 00:00:00
abstract::Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pin...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90066-r
更新日期:1991-05-01 00:00:00
abstract::Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90068-t
更新日期:1991-05-01 00:00:00
abstract::We have used [3H]Senktide, a selective Neurokinin B receptor ligand, for the characterization of NK-3 receptors in rat and guinea pig CNS membranes. Scatchard analysis of saturation binding studies in cerebral cortex membranes indicated that this ligand bound to a single site with apparent high affinity (KD = 4.6 +/- ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90101-n
更新日期:1991-03-01 00:00:00
abstract::In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90105-r
更新日期:1991-03-01 00:00:00
abstract::We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90005-4
更新日期:1991-02-01 00:00:00
abstract::Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90037-y
更新日期:1990-12-01 00:00:00
abstract::This study investigated the nature of the cholecystokinin-like immunoreactivity (CCKLI) in the dorsal horn of the rat spinal cord. Indeed, using the same antiserum, no variation of radioimmunoassayable CCKLI in the dorsal horn of rats treated neonatally with capsaicin could be seen, whereas the density of immunoreacti...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90033-u
更新日期:1990-12-01 00:00:00